The topic of this article is :How to get the most value for money Spain vacation this year. It does not matter what type of vacation you are looking for; family, action oriented or a beach holiday, you can get an all-in-one deal in Barcelona, and quality accommodation for a reasonable price! For a family (or any larger group) the best alternative will most certainly be to rent a Barcelona self catering apartment suited to your needs. This option is both the cheapest and, for most, the more rewarding way to stay in Barcelona as you get to have a more genuine impression of daily life in the city.

Best vacation apartment deal Barcelona

An obvious benefit of staying in an apartment is you are free to plan meals with your family or other travel companions without consideration of closing times etc. Staying close to one of the numerous markets, like the world-renowned La Boqueria, means you will find any type of eatable product you could possibly want to take advantage of having your own kitchen. Furthermore, you can ask the, usually, very knowledgeable professionals who work at the stalls for tips on have to handle what you buy. In any part of Barcelona you are never far from one of the traditional markets. Renting a Barcelona holiday apartment offers the traveler the chance to be more immersed in the local culture, and with all travel companions under one roof it makes it easier to organize your troops in the mornings!

A good deal does not simply mean the lowest price. A good deal for your vacation accommodation also means renting from an officially approved apartment agency! Holadays Barcelona (www.acomodis.com) is such an agency where you can rent official apartments with guarantees that you will actually get what you pay for, in including a safe, central location, a modernized apartment with all comforts (including WIFI, washing-machine, TV and stereo system etc.) and attentive and friendly service.

Your Barcelona Vacation

Renting an apartment for days means staying in one of the central Barcelona districts: In Eixample: the area For architecture buffs and shopaholics. Here you can follow the ruta de modernisme, walking around seeing the great works of Antoni Gaudí and his compatriots including the city's great symbol Sagrada Familia. This central district is also a Mecca for shopaholics with the majestic Passeig de Grácia and Diagonal avenues littered with designer stores.
There is also a vibrant club-scene with an emphasis on clubs you go to gyrate to the latest beats and the area hosts numerous top restaurants, Catalan and international alike. The Barcelona Old Town: For historical architecture, museums, local designer shopping, night life and dining. The medieval part of town with the splendid Santa Maria del Mar as the jewel is an independent designer heaven with lots of discoveries to be made in the maze of backstreets!
This is also place to start a night-out would be the bars in El Born and then head to the clubs in Barri Gotic located in and around Plaza Reial.
If a beach holiday is what you have planned there is a number of accommodation options in the St.Martí district with apartments within walking distance of the beaches. Off-season deals can be as low as less than 70 euros pr. night meaning you could end up paying less than 20 euros per person!

Neurotoxic Research Reveals Impact of Trehalose Sugar

Physicians are learning how to help rid our bodies of neurotoxins. And, it is with a Smart Sugar. They call it alternative medicine. I call it food. More medical and healthcare professions are recommending their patients change the sugar in their sugar bowl.

A 2011 published paper verifies previous research that indicates the sugar trehalose is a powerful modifier of abnormal protein accumulation in neurodegenerative diseases.

Many university studies verify that it is the accumulation of neurotoxic proteins that cause neurodegenerative diseases like Parkinson's, Alzheimer's, and Huntington's. These and other diseases are due to accumulation of abnormal proteins which fold improperly and impair neuronal function.

Neurotoxins increase the rate of cell death. Researchers at the Departamento de Neurobiología-Investigación, CIBERned, Hospital Ramón y Cajal in Madrid, Spain investigated an alternative mechanism for elimination of abnormal proteins, by treatment with the sugar trehalose.

The Abstract states that the sugar trehalose is known to enhance autophagy, protects cells against various environmental stresses. The medical dictionary's definition of autophagy is: a catabolic process involving the degradation of a cell's own components through the lysosomal machinery. It is a tightly regulated process that plays a normal part in cell growth, development, and homeostasis, helping to maintain a balance between the synthesis, degradation, and subsequent recycling of cellular products. It is a major mechanism by which a starving cell reallocates nutrients from unnecessary processes to more-essential processes.

The researchers in Madrid used trehalose as treatment which produced a dose and time dependent increase in the number of autophagosomes and markers of autophagy in NB69 cells.

Trehalose did not change the number of total neither the number of dividing cells in the culture but it completely prevented the necrosis of NB69 induced by epoxomicin. In addition, the treatment with trehalose reverted the accumulation, induced by epoxomicin, of polyubiquitinated proteins, total and phosphorylated tau, p-GSK-3, and á-synuclein, as well as the á-synuclein intracellular aggregates.

The effects of the sugar Trehalose were not mediated through activation of free radical scavenging compounds, like GSH, or mitochondrial proteins, like DJ1, but trehalose reduced the activation of ERK and chaperone HSP-70 induced by epoxomicin. Inhibition of ERK phosphorylation prevented the epoxomicininduced cell death. Inhibition of autophagy reverted the neuroprotective effects of trehalose in epoxomicin-induced cell death.

These results suggest that the Smart Sugar, Trehalose, is a powerful modifier of abnormal protein accumulation in neurodegenerative diseases including Parkinson's, Alzheimer's, and Huntington's.

JC Spencer has invested two decades in the research and study of glycomics, the science of sugars. He is CEO of The Endowment for Medical Research, Inc http://endowmentmed.org References from the textbook Expand Your Mind - Improve Your Brain and the ebook and Change Your Sugar, Change Your Life. The book, Change Your Sugar, Change Your Life is downloadable without charge at http://www.DiabeticHope.com